Stem Cell Therapy for Osteoporosis

osteoporosis

More than 200 million people worldwide suffer from osteoporosis, a disease characterized by porous and fragile bones occurring due to reduced mineral density in the bones. These patients are at an increased risk of suffering from fractures as bone tissue undergoes slow decay and lacks functional strength. Osteoporosis is diagnosed through densitometric analysis of bones and is caused by a several factors including age, sex, smoking, high alcohol consumption, hormonal imbalance, previous history of fractures, genes and diseases such as rheumatoid arthritis. Currently, drugs used for treating osteoporosis such as bisphosphonates or denosumab primarily focus only on inhibiting the process of bone damage and reduce fracture risk. These treatments are ineffective in healing the damaged bones, apart from causing other serious side effects like cancer, heart attacks and blood clots when used for a prolonged duration. Advances in regenerative medicine such as amniotic stem cell allografts offer a promising therapy for repair and restoring of osteoporotic bones.

Advantages of amniotic allografts

Amniotic membranes are a rich source of a special type of stem cells called mesenchymal stem cells. In a study published in Scientific Reports, Dr. Pascale Guillot and his team used human mesenchymal stem cells isolated from the amniotic cells and injected them into mice suffering with osteoporosis. Amniotic cell injections significantly reduced the rate of bone fractures in these mice compared to control mice that did not receive stem cell injections. In addition, transplanted mice also showed significant improvement in mineral density, and toughness in the bones. In studies on human subjects, amniotic stem cell injections restored function in deteriorated joints, lowered joint friction and increased number of cartilage cells. Some clinically useful characteristic features of amniotic stem cells are as follows:

  1. These cells can differentiate into any cell type including bone forming cells, scientifically known as osteoblasts.
  2. Amniotic membrane allografts secrete a number of growth factors that are required for the differentiation of stem cells.
  3. Growth factors released by mesenchymal stem cells also promote wound healing.
  4. Amniotic stem cell allografts have a very low rate of rejection as they create an anti-inflammatory environment. These allografts are also non-tumorigenic as they do not cause formation of tumors.

Injection of amniotic cells is a safe procedure with minimal side effects, which include mild pain at the site of injection, redness, and swelling. Symptoms subside in a week. At Stem X, we use amniotic stem cell allografts routinely for treating patients suffering with osteoporosis and various other orthopedic conditions. Please visit www.stemxgroup.com to know if amniotic stem cells are a right treatment for you, in case you are suffering with osteoporosis.

References

https://www.nature.com/articles/srep39656#results

 

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